MT-RNR2 and proteostasis deficiencies: Thus, while humanin and its analogs are being investigated as potential therapeutics for degenerative, protein-misfolding diseases such as age-related macular degeneration (AMD), Alzheimer disease (AD), Creutzfeldt-Jakob disease (CJD) and diabetes mellitus (DM)5, 6, 9, 12–15, it appears that multiple MDPs may have therapeutic potential.