Given the general paucity of information available regarding MDPs and diabetes-associated protein-misfolding, plus observations that multiple MDPs display cytoprotective phenotypes2, 15, we sought to determine whether the potent humanin analog, HNG, as well as the MDP, SHLP2, could function in a chaperone-like capacity to prevent the misfolding of IAPP. The gene discussed is IAPP; the disease is diabetes mellitus.