The cancer cell lines appear in the upper right corner of the correlation plots (Fig. 2B,C) closely situated to the mesenchymal stem cells, which suggests that the transcriptional pattern involving the coordinated up-regulation of genes controlled by SP1, LEF1, and FOXO4 corresponds to the phenomenon of epithelial-mesenchymal transition (SP1 is known to be involved in epithelial-mesenchymal transition20). The gene discussed is FOXO4; the disease is cancer.