HADHA and cancer: More importantly, cancer cell lines differ from healthy dividing cells in the higher expression of 5 enzymes involved in valine degradation (BCAT2, DBT, DLT, HADHA, and HIBADH), with 4 of them (BCAT2, DBT, DLT, and HADHA) being also involved in isoleucine degradation and 3 in leucine degradation (BCAT2, DBT and DLT) (Supplementary Fig. S2).