In order to determine the relationship between the two large-scale transcriptional patterns (epithelial-mesenchymal transition and AP-1 down-regulation) that appear to differentiate cancer cell lines from healthy dividing cells and the hallmark capabilities of cancer9, we performed enrichment analysis of KEGG31, 32 pathways using DAVID 6.725, 26 (Supplementary file SF3) for the gene sets regulated by SP1, LEF1, and FOXO4 as well as for the consensus down-regulated genes and consensus up-regulated genes (found in both microarray and RNA-seq analysis). This evidence concerns the gene LEF1 and cancer.