Similarly, when EL-4 cells were injected in WT mice, Grail but not Cbl-b expression was selectively upregulated in CD8+ T cells infiltrated in tumours (Supplementary Fig. 1c and d), suggesting that both strong or weak immunogenic tumours selectively induced Grail expression in tumour-infiltrating CD8+ T cells in vivo. This evidence concerns the gene CBLB and neoplasm.