These pathways include 77 genes among which are the following hallmarks of AD: WNT10B, DKK1, and FZD5 (up-regulated); TCF7L2 and LRP6 (down-regulated); ANXA1, PSEN-1, PSEN-2, APOE, CTNNB1 (up-regulated); MTRNR2L2 (down-regulated). Here, APOE is linked to Alzheimer disease.