VEGFA and early-onset autosomal dominant Alzheimer disease: The list includes genes from 131 signaling pathways (Supplementary Table S2), some of which are indirectly relevant to AD (inflammation, angiogenesis, VEGF and Wnt signaling) (Table 1) and some more directly relevant (Alzheimer disease-amyloid secretase, and Alzheimer disease-presenilin) (Table 2).