And he also mentioned that tumor stem cells derived from glioblastomas cultured in the presence of basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) mirror the phenotype and genotype of primary tumors more closely than cell lines cultured in the presence of serum, which would be a better human glioma cell model. This evidence concerns the gene FGF2 and glioblastoma.