Although the impact of oxidative stress on a number of proteins with pro-resolving roles in pathogenesis of COPD are well recognised (e.g. transcriptional corepressor histone deacetylase 2 and sirtuin 1 (reviewed in [101]), the importance of the loss of MKP-1 function due to oxidisation is currently underappreciated and warrants further investigation. The gene discussed is DUSP1; the disease is chronic obstructive pulmonary disease.