INS and diabetes mellitus: It is true that Sobngwi and co-workers demonstrated that fasting insulin sensitivity indices like HOMA-IR are modest predictors of insulin sensitivity measured by euglycemic clamp in non-diabetes African subjects [26], Noteworthy, Bonora and co-workers bolstered a strong correlation between the HOMA-IR and the hyperinsulinemic euglycemic clamp in the general population, which enabled them to recommend using the HOMA-IR in conditions where realization of the clamp method is not easy [27].