IL4 and Cowden syndrome 1: PBMCs isolated from CS patients secreted increased levels of Th2 cytokines IL-4, IL-5 and IL-13, and decreased secretion of the Th1 cytokine IFN-γ as compared to OS upon stimulation with scabies mite antigens [35], similar to those seen with Der p 1 and HDM allergy [99].