The multiple linear regression analysis results after age, sex, and DM status were adjusted showed that SELENOS SNP rs4965373 correlated with the serum insulin level, SELENOS SNP rs4965814 correlated with the blood glucose level and HOMA-IR, and SELENOS SNP rs28665122 did not correlate with the above metabolic risk factors. The gene discussed is SELENOS; the disease is diabetes mellitus.