Studies showed that the ER stress inducers tunicamycin (TM), thapsigargin (TG), and β-mercaptoethanol could up-regulate SELENOS expression in RAW264.7 macrophages, HepG2 liver cancer cells, HEK293T human embryonic kidney cells, and mouse astrocytes [21, 60–62], suggesting that SELENOS is involved in the regulation of ER stress. Here, SELENOS is linked to liver cancer.