Patients in these two groups were subjected to a euglycemic-hyperinsulinemic clamp, and the expression of SELENOS mRNA in subcutaneous adipose tissues increased in patients of the T2DM group (1.67-fold), with no significant change in the healthy control group, suggesting that high insulin could increase SELENOS expression in subcutaneous adipose tissues in T2DM patients. The gene discussed is SELENOS; the disease is type 2 diabetes mellitus.