To test whether dgPMCAb-derived PrPres induced prion disease in animals, Syrian hamsters were inoculated with the products of serial dgPMCAb reactions seeded with (i) the lysates of HeLa cells expressing α-synuclein A30P or (ii) WT α-synuclein fibrils produced in vitro (Table 1). Here, SNCA is linked to prion disease.