Consistent with cell line data, elevated O-GlcNAcylation on GNB2L1, as well as the increase of OGT instead of OGA, was observed in chemoresistant patients (Fig 2B), confirming the critical role of OGT for the O-GlcNAcylation on GNB2L1 in gastric cancer chemoresistance. The gene discussed is OGT; the disease is gastric cancer.