And further we found that the inhibitor of protein biosynthesis, cycloheximide (CHX) managed to abrogate the GNB2L1-reversed EMT in SGC-7901/DDP cells (Fig 4F), indicating that GNB2L1 modulated EMT via regulating the translation of EMT-related proteins in the process of gastric cancer chemoresistance. This evidence concerns the gene RACK1 and gastric cancer.