Results showed that OGT levels varied a lot between SGC-7901 cells and chemoresistant cells whereas no obvious difference of OGA levels was observed (Fig 2A), indicating that the expression level of OGT instead of OGA is the major factor influencing the O-GlcNAcylation of GNB2L1 in gastric cancer chemoresistance. This evidence concerns the gene OGT and gastric cancer.