Interferon (IFN) has long been used for anti-HCV therapy, and achievement of sustained virological response (SVR) by peg-interferon plus ribavirin (PEG-IFN/RBV) therapy could reduce the incidence of HCC development in patients with chronic HCV infection by reducing liver inflammation, fibrosis, and serum alanine aminotransferase (ALT) levels [5–10]. The gene discussed is GPT; the disease is hepatocellular carcinoma.