In their study, laser-captured CA1 pyramidal neurons from cases assigned a Braak stage III diagnosis exhibited a 35% increase in CatB protein as compared to nondemented control groups, whereas a smaller, insignificant change in CatB was found in neurons from the more severe Braak stage V. Thus, the reported higher CatB levels in AD may be an indication of a compensatory lysosomal response, and perhaps the weaker response in more severe cases explains an increased vulnerability that leads to worsening cognition and higher Braak rating. The gene discussed is TYRP1; the disease is Alzheimer disease.