PAPPA and congestive heart failure: One study that included up to 1258 patients with acute MI showed that several candidate markers, that is, NT-proBNP, midregional proatrial natriuretic peptide (MR-proANP), sST2, troponin T, myeloperoxidase (MPO), hsCRP, and pregnancy-associated plasma protein-A (PAPP-A), were significantly associated with 30-day risk of cardiovascular death or CHF after adjusting for clinical predictors [18].