LDLR and intracerebral hemorrhage: While this is contrary to the histological results gathered in the microvasculature of SHRSP [7], our findings in Ldlr-/- mice are, however, in line with clinical studies showing that (i) low serum cholesterol levels are associated with an increased number of cerebral microbleeds and with ongoing hematoma growth after large intracerebral bleeding, and that (ii) statin-use is not related to intracerebral hemorrhage occurrence [14, 28–31].