CD274 and gastric cancer: Beyond the differential presence of PD-L1+ cells in EBV+ and EBV- GC, Derks et al.[40] observed a difference in infiltration pattern of PD-L1 positive immune cells; while PD-L1+ immune cells were able to infiltrate the center of EBV+ and MSI GC, in EBV- and MSS GC PD-L1+ immune cells stayed mainly at the invasive margin.