1105 cases of steroid resistant nephrotic syndrome (SRNS) from pediatric nephrology clinical centers in European and Middle East countries enrolled through the PodoNet SRNS Registry [4], and the in-house biobanks at Necker Hospital in Paris, France, Medical University of Gdańsk, Poland and Hacettepe University Nephrogenetics Laboratory, Ankara, Turkey were systematically screened as part of SRNS-related gene panel analysis, including 308 patients negative for mutations in the first-line SRNS-associated genes (NPHS2, exons 8–9 of WT1). The gene discussed is NPHS2; the disease is steroid-resistant nephrotic syndrome.