During corneal infections, IL-1β, IL-6, IL-8, and TNFα are important in the initiation of inflammatory signals [68] and both TLR2 and TLR5 mediate microbial clearance and cytokine production during S. aureus and PA keratitis [6,11,14,17,18,69]. This evidence concerns the gene CXCL8 and keratitis.