In accordance with previous reports that NF-κB signal pathway and its downstream chemokine IL-8 contributes to inflammation and to every step of CRC progression proliferation, migration and invasion,26, 27, 28 we found that NF-κB inhibition and IL-8 depletion eliminates the tumor-promoting activity of RNF183. Here, CXCL8 is linked to colorectal carcinoma.