Furthermore, we found that the expression levels of DUSP5 and CDKN1A were increased in si-EZH2-treated CRC cells (P<0.05) (Figure 6d), implying DUSP5 and CDKN1A may be the key downstream genes of CRNDE, and CRNDE can inhibit its expression by binding to EZH2. This evidence concerns the gene CDKN1A and colorectal carcinoma.