CRNDE and colorectal carcinoma: Furthermore, we found that the expression levels of DUSP5 and CDKN1A were increased in si-EZH2-treated CRC cells (P<0.05) (Figure 6d), implying DUSP5 and CDKN1A may be the key downstream genes of CRNDE, and CRNDE can inhibit its expression by binding to EZH2.