Distal-less homeobox 2 (DLX2) plays an important role in control of cell migration,13 proliferation,14 differentiation,15 neurogenesis16, 17 and pattern formation.18 Downregulation of DLX expression has been reported in human solid and hematologic malignancies, and in lymphoblastic leukemias.19, 20, 21. The gene discussed is DLX2; the disease is acute lymphoblastic leukemia.