As shown in Figure 1, while human non-small cell lung cancer H1299 cells, which do not express endogenous p53, grew into typical epithelial morphology exhibiting tightly packed colonies and formed a continuous sheet with no intercellular spaces, expression of either p53-R175H, p53-R248W or p53-R273H led to scattering cell growth with mobile cell morphologies showing lamellipodia on the leading edge of the cells (Figures 1a and b). This evidence concerns the gene TP53 and non-small cell lung carcinoma.