Taken together, our study reveals a new pathway with which mutant p53-R273H suppresses DLX2 transcription, resulting in downregulation of NRP2 expression, which in turn leads to attenuation of signaling transduction pathway involved in TGFβ, SEMA3 and vascular endothelial growth factor in epithelial-mesenchymal transition, cell mobility and cancer metastasis (Figure 6e). The gene discussed is DLX2; the disease is cancer.