NRP2 functions as a co-receptor of SEMA3, vascular endothelial growth factor and transforming growth factor β 1 and is important for cell proliferation, survival, epithelial-mesenchymal transition and metastasis.22 It has recently become widely acknowledged that upregulation of NRP2 expression is associated with tumorigenesis and, in particular, tumor metastasis.23 This evidence concerns the gene NRP2 and neoplasm.