TP53 and cancer: It is well documented that hotspot mutations of p53 gene, in particular, R175H, R248W and R273H, are loss of function alleles as they are unable to transactivate downstream genes involved cell growth control and apoptosis.24 However, it becomes clear that these mutant alleles, in addition, exhibit gain of new functions in promoting tumorigenesis, including promoting cancer metastasis,25 yet the molecular mechanisms are not totally understood.