EGLN3 and digestive system infectious disorder: The three PHD variants in mammalia differ regarding organ-specific expression, their inducibility in hypoxia and other non-HIF-related functions.16 Especially, PHD3 has been associated with cell survival decisions and altered macrophage function.17 A myeloid-specific knockout of PHD3 affects cell survival and apoptosis of neutrophils and macrophages.18 In the context of bacterial lung or intestinal infections, it has been demonstrated that a myeloid-specific PHD3 knockout results in hyperinflammation.19, 20 The consequences for a non-sterile ischemic inflammation, however, are unknown.