TNF and colitis: Macroscopic or histological colitis as demonstrated by colon shortening and hematoxylin and eosin (H&E) histological scoring of inflammation in C57/BL6 mice (7.22±0.42) was not significantly different from TNFα KO mice (6.81±0.15); however, the colon length of both groups were significantly longer than Winnie (6.01±0.27) and TNFα KO Winnie (6.13±0.20) if compared with WT mice (Figures 2a and b).