TNF and inflammatory bowel disease: A common ground for this multifactorial disorder is an increased production of diverse panel of cytokines,2, 3 some of which are pro-inflammatory and hence targets for therapeutic blockade.4 Among the cytokine milieu dysregulated in IBD-like chronic inflammatory conditions, tumor necrosis factor α (TNFα) is a major pro-inflammatory cytokine that drives downstream immune responses resulting in IBD.