Neuronal death and functional abnormality due to Aβ oligomers have been considered to be the main cause of AD.1, 47 OSNs are also cell-autonomously degenerated by OSN-specific expression of the Swedish mutated form of the human APP gene.21 In the current study, TUNEL-positive cells appeared to be almost entirely located in the OSN layer in Tg2576 mice, and in vitro cultured OSNs were cell-autonomously degenerated after treatment with the Aβ oligomer. The gene discussed is APP; the disease is Alzheimer disease.