Additionally, statins augment the efficacy of various antitumor therapeutics in different tumor entities.55, 56 Noteworthy, pitavastatin acts as a radiosensitizer for multiple tumor cell types including lung tumor cells57, 58, 59 and, furthermore, radiosensitization of breast carcinoma cells60 and head and neck squamous cell carcinoma (HNSCC) cells61 is achievable by Rac1 inhibition. Here, RAC1 is linked to breast carcinoma.