YAP as a key downstream transcription factor of the Hippo signaling pathway plays a critical role in cell proliferation and apoptosis.23, 24 In addition, overexpression of YAP correlated with poor overall survival of glioma patients.36 However, little is known about whether YAP is involved in DACT2’s regulation of glioma cells proliferation and apoptosis. This evidence concerns the gene DACT2 and central nervous system cancer.