We first examined the protein levels of DACT2 in 80 gliomas tissues and 10 normal brain tissues by immunohistochemistry (IHC), the result showed all normal brain tissues expressed DACT2 at higher levels, while glioma tissues with different grades showed apparently lower levels of DACT2 expression (Figures 1a and b). The gene discussed is DACT2; the disease is glioma.