Dapper homolog 2 (DACT2) belongs to DACT gene family, located on human chromosome 6q27 which is a region frequently related to loss of heterozygosity in human cancers.8, 9, 10, 11, 12 There are three members in DACT family, including DACT1, 2 and 3.13 DACT1 is located on human chromosome 14q22.3 and has been revealed frequently to be methylated in hepatocelluar carcinoma. This evidence concerns the gene DACT1 and cancer.