In addition, IHC assay revealed that DACT2 overexpression upregulated the expression of Bax and downexpressed the expression of YAP, PCNA and CyclinD1 and in glioma tissues (Figures 9d and e), and DACT2 knockdown caused opposide result (Supplementary Figure 3D and E). The gene discussed is CCND1; the disease is central nervous system cancer.