KEAP1 and familial dilated cardiomyopathy: Meanwhile, some evidence has revealed that Keap-1 has a pivotal role in ubiquitin aggregate clearance via autophagy in HEK293T cells.16 Although our previous study reported that H2S could attenuate the apoptosis of DCM induced by type 1 diabetes,17 the mechanism is not very clear between H2S and DCM.