KEAP1 and familial dilated cardiomyopathy: Studies also indicate that H2S could promote disulphide formation between two Kelch-like ECH-associated protein 1 (Keap-1) molecules.14 Zhou et al.15 have demonstrated that exogenous H2S could prevent the development of DCM by reducing ROS production through the Keap-1-nuclear respiratory factor 2 (Nrf2) signalling pathway.