The subcutaneous tumor burdens induced by TL‐1 cells were almost completely suppressed by anti‐PD‐L1 mAb + Lm‐LLO‐E6 vaccine or anti‐PD‐L1 mAb + Lm‐LLO‐E6/E7 vaccine when compared with the control group. Here, CD274 is linked to neoplasm.