In addition, the involvement of HPV16/18 infection in lung tumorigenesis was partially through p53 inactivation 10, increased hTERT 20 and IL‐10 expression 11, and decreased TIMP‐3 expression in HPV16‐infected TL‐1, TL‐2, or TL‐3 cells 12. Here, TIMP3 is linked to infection.