Such a change of glutamate release should alter NMDA receptor (NMDAR)‐mediated cell death in ischemia (Brassai, Suvanjeiev, Ban, & Lakatos, 2015; Vornov and Coyle, 1991) and thus contribute to the neuroprotective effect in ischemia of GPR37L1 and prosaptide [see below and Morita et al. (2001)]. This evidence concerns the gene GPR37L1 and ischemia.