However, prosaposin expression and release are increased in ischemia (Costain et al., 2010; Hiraiwa et al., 2003) and we found that expression of Gpr37l1 is increased in the penumbra of lesions caused by MCAO (Figure 8), so it is likely that glutamate transport activity is inhibited in these conditions. The gene discussed is GPR37L1; the disease is ischemia.