Notably, while the prevalence of Klotho deficiency in our CKD-T population was low (12%) in comparison to the prevalence of FGF23 levels of ≥95th percentile (42%), both low Klotho levels and high FGF23 levels were determinants for worse cardiac diastolic function. This evidence concerns the gene FGF23 and hyperinsulinemic hypoglycemia, familial, 4.