Hence, host responses including cytokine, cell markers, receptor biomarkers, coagulations, vascular endothelial damage, vasodilation, organ failure and scientific advancement in the field of molecular biology can equip us to screen wide range of protein markers in acute phase of sepsis development that helps in identifying relevant biomarkers to diagnose sepsis [16].WBC, C-reactive protein (CRP) and interleukin-1 (IL-1) are the conventional markers used for diagnosis of sepsis. The gene discussed is CRP; the disease is Sepsis.