In a recently published study on the mutational analysis of APML by Madanet al. from the Cancer Science Institute of Singapore, a comprehensive mutational landscape of primary and relapsed APML was unveiled26; 153 primary and 69 relapsed APML samples were explored by using whole-genome sequencing (n = 12) and subsequent targeted sequencing of 368 genes.FLT3 emerged as the most frequently altered gene in primary APML samples. The gene discussed is FLT3; the disease is acute promyelocytic leukemia.