Intriguingly, our study failed to show elevated serum TNFα, IL-6, IFNβ, IL-8, IL-10, IL-12 and IFNγ levels in T2DM subjects despite perturbations in cytokine/TLR mRNAs levels being evident in the monocytes and neutrophils taken from T2DM patients. The gene discussed is TNF; the disease is type 2 diabetes mellitus.