BARD1 and neoplasm: Multivariate analyses indicated that high tumor expression of BARD1 (hazard ratio [HR], 1.769; 95% CI, 1.184–2.644; P = 0.005), size of tumor >5 cm (HR, 2.420; 95% CI, 1.468–3.991); P = 0.001), TNM stage III–IV (HR, 1.698; 95% CI, 1.026–2.809; P = 0.039), and increased serum AST levels (HR, 1.664; 95% CI, 1.072–2.582; P = 0.023) were independent predictors of a shorter PFS in HCC patients (Table 2).