BARD1 and neoplasm: Accumulating evidence showed the tumor-suppressor function of BARD119, however, we reported the up-regulated expression of BARD1 significantly correlated with an unfavourable prognosis in HCC, which most probably because the aberrant form of BARD1 caused by differential splicing resulted in a compromised tumor-suppressor activity with the tumor microenvironment, contributed to the tumorigenesis of HCC.