Beyond the direct activation of TACE α-secretase by ROS through modification of the valence state of Zn2+ at the catalytic site16, redox activation of guanylate cyclase (GC) and subsequent production of cGMP was also shown to promote TACE-dependent TNFR1 shedding in sepsis conditions17. This evidence concerns the gene TNFRSF1A and Sepsis.