LEP and Alzheimer disease: The Tb.N in leptin-treated offspring was 4.07 (3.88, 4.25), 0.37 more (P = 0.011) than in saline-treated controls (3.50, 3.89), (P = 0.011), except in AD-HF offspring as shown in the significant interaction of maternal nutrition and leptin (Fig. 3).