The BV/TV in UN and AD groups was similar (P = 0.37), but higher in chow- than HF-fed groups (P = 0.0001), and higher in leptin- than saline-treated UN groups (P = 0.035) but lower in leptin-treated AD group fed HF diet (UN-L interaction P = 0.0167). Here, LEP is linked to Alzheimer disease.