SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: Three of the 8 patients with Thr226Met (cases 3, 4, and 6) have been previously reported as having Dravet syndrome.2,5 Case 6 was identified in 2007 in our large study delineating the phenotypic spectrum of Dravet syndrome.2 Cases 3 and 4 were drawn from a 2014 study of sleep problems associated with SCN1A-confirmed Dravet syndrome,5 but the phenotype was not described in the report.