Despite considerable effort, no phenotype-genotype correlation has been shown for the hundreds of SCN1A mutations identified, with the majority associated with Dravet syndrome and a small proportion with GEFS+.4 Here, we show a phenotype-genotype correlation for SCN1A describing a distinct SCN1A phenotype, early infantile SCN1A encephalopathy, that is far more severe than Dravet syndrome. The gene discussed is SCN1A; the disease is Encephalopathy.