Melanomas arising in chronically sun-damaged skin, mucosal surfaces, and acral skin were cause by over-activate BRAF and NRAS [47], loss of the CDKN2A locus [48], overexpressed the MITF [49], overactivate Kit [50], over-activate mGluR1 [51, 52]...et al. In this study, 10-HDA could inhibit MITF expression in B16F10 melanoma cells. This evidence concerns the gene NRAS and melanoma.