WT1 and acute myeloid leukemia: In acute myeloid leukemia cells, induction of Wilms' Tumor 1 (WT1) lncRNA, an antisense-oriented lncRNA overlapping with intron 1 CpG island of the WT1 gene, appears to be the result of demethylation through hypoxia-regulated expression of DNA methyltransferase 1 and tet methylcytosine dioxygenase 2 (83).