SAV1 and neoplasm: It has been defined that core to the Hpo pathway is a kinase cascade composed of tumor suppressors Hpo, Salvador(Sav), Mob-as-tumor-suppressor(Mats), and Warts(Wts)[11–12,19–22], which ultimately phosphorylates and inactivates the transcriptional coactivator Yorkie(Yki), the most critical downstream effector of the Hpo pathway[23–24].