Several agents have been used for the treatment of osteoporosis, including: bisphosphonates (alendronate, ibandronate, risedronate, and zoledronic acid), calcitonin, selective estrogen receptor modulators (raloxifene), parathyroid hormone (teriparatide), and RANK-ligand inhibitors (denosumab) [20]. Here, ESR1 is linked to osteoporosis.