Significantly higher expression of FAP in the VERA group was seen in the seronegative persistent RA subgroup after excluding RA patients with self-limiting or seropositive disease (p = 0.0035 individual comparisons p<0.05, Fig 1A red data points), suggesting that FAP could be a useful biomarker for seronegative persistent RA. The gene discussed is FAP; the disease is rheumatoid arthritis.