MTTP and obesity due to melanocortin 4 receptor deficiency: While our studies and those of Bakillah and Hussain [3] are in agreement that decreased expression of MTP in adipose tissue leads to smaller lipid droplets and decreased adipocyte size, our results do not support the conclusion that decreased expression of MTP in adipose tissue produces resistance to high fat diet-induced obesity or protection from high fat diet-induced fatty liver.