CASP8 and infection: Compared to the group of infected monocytes without IETD treatment, IETD blocked the induction of apoptosis in PBMO and CBMO, suggesting that in both, PBMO and CBMO caspase-8 activation is a prerequisite for the induction of apoptosis after infection (Fig 5, 2nd vs. 3rd column; p < 0.05).