CASP8 and infection: Infection with E. coli led to increased cleavage of caspase-8 in PBMO (p<0.01; Fig 4B), while this effect was strongly reduced in CBMO 120 min p.i. Caspase-8 activation was time-limited, because 240 min p.i., both, PBMO and CBMO did not show caspase-8 activation significant different to the non-infected controls (Fig 4B).