REN and Ascites: According to the pathophysiology of ascites, the appearance of HRS type 2 is one of the expected complications in advanced stage cirrhotic patients with ascites, when the activation of the neurohumoral system, renin-angiotensin-aldosterone, SNS, and antidiuretic hormone (ADH) are extreme and can no longer return the balance of the hemodynamic parameters to normal levels of blood pressure.