RPS6KB1 and neoplasm: However, the high expression of p-RPS6KB1 was more frequent in regional lymph node involved or advanced stage cases (Table 2, P = 0.033 and < 0.001, respectively), though there was no association between p-RPS6KB1 overexpression and gender, age, histological type, differentiation, tumor size or distant metastasis (all P > 0.05).