Observations in esophageal squamous cell carcinoma that p-RPS6KB1 had a robustly positive expression in tumor tissues and closely related to the regional lymph node metastasis and advanced clinical stage provided more evidence that p-RPS6KB1 is probably the activated form of RPS6KB1 to exert its pathophysiological function in several kinds of tumors, including NSCLC [31]. Here, RPS6KB1 is linked to neoplasm.