Univariate Cox proportional hazards regression analysis was then employed to explore the clinicopathological significance of RPS6KB1, and the differentiation, tumor size, regional lymph node involved, distant metastasis, clinical advanced stage and the expression of p-RPS6KB1 were found to be significant prognostic factors (Table 5, all P < 0.05). This evidence concerns the gene RPS6KB1 and neoplasm.