INPP5D and neoplasm: Similar to SHIP1, SHIP2 functions as a tumor suppressor in glioblastoma, erythroleukemia and squamous cell carcinoma (Giuriato et al., 2002; Taylor et al., 2000; Yu et al., 2008), but is oncogenic in breast carcinomas and colorectal cancer (Hoekstra et al., 2016; Prasad et al., 2008).