TP53 and neoplasm: Specifically, serous tubal intra-epithelial carcinoma (STIC), developed via acquisition of a p53 signature in a distal oviduct fimbriae tumor-initiating cell, is considered to be the site of tumor initiation, while tumors on the ovary and peritoneal surfaces are thought to be secondary lesions [27,28,29,30,31,32].