During EMT, epithelial-type cancer cells undergo a set of molecular, morphological and functional changes with the loss of Ecad and gain of Ncad, which result in impaired epithelial cell-cell junctions and cell polarity, acquisition of a mesenchymal motile cell phenotype, and labile bonding with Ncad-expressing fibroblasts [8,9], endothelial cells and pericytes [10,11]. The gene discussed is CDH2; the disease is cancer.