Still in another study, IL-22 was combined to TNF-α, IL-4, and IL-13 and applied together as an “AD-mix” on RHE at day 10 of epidermis reconstruction for 48 h at a concentration of 3 ng/ml (90) in order to compare this set of interleukins with another “psoriasis-mix” set of interleukins containing IL-17, a psoriasis-related cytokine, instead of Th2 cytokines IL-4 and IL-13. Here, TNF is linked to psoriasis.