TSLP and allergic rhinitis: TSLP is believed to be a systemic driver for bronchial hyperresponsiveness since blockade of TSLP signaling (36) or inducible gene deletion of TSLP in mice keratinocytes (37, 38) prevents occurrence of the atopic march, suggesting a potential direct link between AD and allergic asthma and/or allergic rhinitis (39–41).