For example, IL-4, IFN-γ, and TNF-α were reported to trigger the production of other chemokines, like IL-8, C–C motif chemokine ligand 5, RANTES, or C–X–C motif chemokine ligand 10 in keratinocytes from non-lesional AD skin (70). This evidence concerns the gene CXCL8 and Alzheimer disease.