Recombinant SAP130 triggers pro-inflammatory cytokine secretion such as MIP-2 from peritoneal macrophages in a FcγR chain-dependent manner (4).The relevant role of Mincle for endogenous inflammatory conditions is corroborated by concomitant upregulation of Mincle, SAP130, and phospho-Syk expression in ischemia (29), pancreatic ductal adenocarcinoma (PDA) (28), as well as ethanol-induced liver injury (30). Here, CLEC4E is linked to pancreatic ductal adenocarcinoma.